Dedicated to the mother of Achilles, the 'Thetideion Ieron' (the Sanctuary of Thetis) is mentioned in Euripides' "Andromache". Archeologists place the sanctuary 2 km away from Skotoussa, at the location of the modern village Thetideion. Ruins have been discovered in the village.

Some of the ancient cities of the region (the modern county of Farsala) were the following: Skotoussa, Eretria, Pevma, Enydrion, Palaiofarsalos and the most important and famous of them all, Farsalos.

Skotoussa:
Skotoussa was an ancient city of Pelasgiotida in Thessaly, located between Feres and Farsala. During the 5th and 4th centuries BC it was one of the most remarkable cities of the entire region. Its cavalry, which fought against Agisilaos in 394 BC, was considered to be one of the finest of the entire region. In 368 BC the tyrant of Ferai Alexander conquered the city and later on, following its conquest by the King of Macedonia Philip the Second, it was turned into a Roman military operation center. The decline of the city started at the end of the 2nd century BC. Its ruins are still salvaged today in the homonymous village of the county of Farsala. Remarkable coins, dating from the period between the 5th century and 200 BC were also found in the region. Findings are currently exhibited at the museum of Larissa.

Today, Skotoussa is a semi-mountainous settlement of the county of Farsala and the seat of the homonymous community. The villages Agia Triada, Ano Skotoussa, Agios Konstantinos and Thetideio also belong to the community.

Polydamas:
The son of Nikios Polydamas, who was the Olympic winner of "Pangratio" during the 93rd Olympic Games held in 408 BC, originated from Skotoussa. Polydamas was famous not only because of his Olympic victory, but also due to the fact that according to Pafsanias, his life was nothing but as series of deeds testifying to his strength, which made him equal to demigods and legendary heroes such as Hercules.

The Munipality of Polydamantas of the Farsala county was named after Polydamas.