Farsala suffered during the Second World War because of its location. It was bombarded during the first days of April 1941 by German airplanes, which caused many damages to the city. It also paid a heavy price for the participation of its residents in the National Resistance.

The city was set on fire by the Italians at the end of March 1943 and approximately 200 people were executed in retaliation for the partisans' action.